Zulfidin 500mg Tablet 10pcs

✔️ Uses of Zulfidin 500

• Ulcerative colitis
• Crohn’s disease
• Rheumatoid arthritis

✔️ How does Zulfidin 500 work?

works by suppressing the overactivity of the immune system in autoimmune diseases and blocks the chemical messengers that cause inflammation (swelling).

✔️ Side Effects: Zulfidin 500

• Headache
• Indigestion
• Nausea
• Watery diarrhoea

✔️ Pharmacology

The exact mode of action of Sulfasalazine is still being studied. However, it is believed to work through its anti-inflammatory and/or immunomodulatory properties, which have been observed in both animal and in vitro models. Other potential mechanisms include:

1. Affinity for Connective Tissue: Sulfasalazine has been found to bind to connective tissue.
2. High Concentrations in Specific Areas: It accumulates in serous fluids, the liver, and intestinal walls, as demonstrated by autoradiographic studies in animals.

Ulcerative Colitis:

Clinical studies involving the rectal administration of Sulfasalazine, its metabolite Sulfapyridine, and 5-aminosalicylic Acid (5-ASA) suggest that the primary therapeutic effect is due to the 5-aminosalicylic Acid moiety.

Rheumatoid Arthritis:

The specific contributions of Sulfasalazine and its major metabolites to the treatment of rheumatoid arthritis remain unknown. Further research is needed to understand its precise mechanism in this condition.

✔️ Important Notes:

• Dosage should be adjusted based on individual response and tolerance.
• Always consult with a healthcare provider before starting or adjusting the dosage.
• Regular monitoring of blood, liver, and kidney function is recommended during treatment.

✔️ Dosage & Administration of Zulfidin 500

The dosage of Sulfasalazine tablets should be tailored to each patient based on their tolerance and response to treatment. It is typically taken in evenly divided doses, preferably after meals, to reduce gastrointestinal discomfort.

Dosage Guidelines:

For Crohn’s Disease (Adults):

• Dosage: 500 mg orally, 2 to 4 times a day with food.

For Ulcerative Colitis (Pediatrics - Age 6 and Older):

• Initial Dose: 40 to 60 mg/kg/day, divided into 3 to 6 doses.

For Rheumatoid Arthritis (Adults):

• Maintenance Dose: 2 g daily, divided into two doses.
• Initial Therapy: Start with a lower dose (0.5 to 1 g daily) to minimize gastrointestinal intolerance.
  • Suggested Schedule:
    • First Week: One tablet in the evening.
    • Second Week: One tablet in the morning and one in the evening.
    • Third Week: One tablet in the morning and two in the evening.
    • Fourth Week: Two tablets in the morning and two in the evening.

For Rheumatoid Arthritis (Pediatrics - Age 6 and Older):

• Initial Dose: 10 mg/kg/day, divided into two equal doses.

For Juvenile Rheumatoid Arthritis (Polyarticular Course):

• Children (Age 6 and Older): 30 to 50 mg/kg/day, divided into two doses.

• Maximum Dose: Typically 2 g/day.

For Other Indications:

• Initial Therapy:
  • Adults: 3 to 4 g daily, divided into doses at intervals not exceeding 8 hours. Start with a lower dose (1 to 2 g daily) to reduce gastrointestinal intolerance.
  • Children (Age 6 and Older): 40 to 60 mg/kg/day, divided into 3 to 6 doses.
• Maintenance Therapy:
  • Adults: 2 g daily.
  • Children (Age 6 and Older): 30 mg/kg/day, divided into 4 doses.

✔️ Inform your doctor if you are currently taking any of the following medications:

• Medications for high blood sugar: Examples include metformin and glipizide.
• Digoxin: Used for managing heart failure.
• Folic acid or folate supplements: For reducing the risk of neural tube defects (e.g., in conditions like spina bifida).
• Azathioprine and mercaptopurine: These medications suppress the immune system, often used in organ transplantation and chronic inflammatory conditions such as rheumatoid arthritis.
• Methotrexate: Commonly prescribed for managing rheumatoid arthritis.
• Methenamine: Used for the treatment of urinary tract infections (UTIs).

✔️ Overdosage Instructions:

• If you or someone else accidentally consumes too much of Zulfidin 500, seek immediate medical attention or visit the nearest hospital.
• Symptoms of overdose: These may include nausea and vomiting.

✔️ Storage

• Keep Zulfidin 500 out of reach of children
• Store below 25°C